References

It is important for me as a naturopathic practitioner to make sure all blogs are factual and supported by referencing. All information has come from the latest clinical trials and research papers at the time of printing.

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Alzheimers update

1. Aggarwal N, Shah R, Bennetti D. Alzheimer's disease: Unique markers of diagnosis & new treatment modalities. October 2015; 142(4):369-382. Doi:10.4103/0971-5916-169193

2. Berti V, Murray J, Davies M, Spector N, Tsui W, Williams S, Pirraglia E, Vallabhaiosula S, McHigh P, Pupi A, de Leon M, Mosconi L. Nutrient patterns and brain biomarkers of alzheimer's disease in cognitively normal individuals. Journal of Nutrition, Health and Ageing. April 2015;19(4):413-423

3. Sivaraman D, Anbu N, Kumar P, Shanmugapriya P, Christian G. Review on current treatment strategy in alzheimer's disease and role of herbs in treating neurological disorders. January 2019; 1(1):33-43

4. Szeto J, Lewis S. Current treatment of alzheimer's disease and parkinson's disease dementia. Current Neuropharmacology. May 2016;14(4):326-338

5. Godyn J, Jonczyk J, Panek D, Malawska B. Therapeutic stratagies for alzheimer's disease in clinical trials. February 2016;68(1):127-138. Doi:10.1016/j.pharep.2015.07.006

6. Jessen F, Kaduszkiewicz H, Daerr M, Bickel H, Pentzek M, Riedel-Heller S, Wagner M, Weyerer S, Wiese B, van den Bussche H, Broich K, Maier W. November 2010;260(2):111-115. Doi:10.1007/s00406-010-0156-4

7. Veld B, Ruitenberg A, Hofman A, Launer L, van Duin C, Stifnen T, Breteler M, Stricker B. Non-steroidal anti-inflammatory drugs and the risk of alzheimer's disease. New England Journal of Medicine. 345:1515-152

8. Zandi P, Anthony J, Hayden K, Mehta K, Mayer L, Breitner J. Reduced incidence of AD with NSAID but not H2 receptor antagonists. Neurology. 59:880-886

9. Xu W, Tan L, Wang H, Jiang T, Tan M, Tan L, Zhao Q, Li J, Wang J, Yu J. Meta-analysis of modifiable risk factors for alzheimer's disease. Cognitive Neurology Research paper. Doi:10.1136/jnnp-2015-310549

10.Adlard P & Bush A. Metals and alzheimer's disease: How far have we come in the clinic? Journal of Alzheimer's Disease. March 2018;62(3):1369-1379. Doi:10.3233/JAD-170662

11.Soininen H, Solomon A, Visser P, Gendrix S, Blennow K, Kivipelto M, Hartmann T. 24-month intervention with a specific multinutrient in people with prodromal alzheimer's disease (LipDiDiet): a randomised, double-blind, controlled trial. The Lancet Neurology. December 2017;16(12):965-975

12.Agosti P, Custodero C, Schilardi A, Valiani V, D'Introno A, Lozupone M, Panza F, Bibello V, La Montagna M, D'Urso F, Solfrizzi V, Sabba C. Nutritional interventios in patients with alzheimer's disease and other late-life cognitive disorders. 2018;66:101-118

13.Vlachos G. Dietary interventions in mild cognitive impairment and dementia. Dialogues in Clinical Neuroscience. March 2019;21(1):69-82.

14.Anweiler C, Llewellyn D, Beauchet O. Low serum vitamin D concentrations in alzheimer's disease: A systematic review and meta analysis. Journal of Alzheimer's Disease. January 2013;33(3):659-674

15.Gremm M, Lauer A, Grosgen S, Thiel A, Lehmann J, Jantschke D, Herr C, Beisswenger C, Bals R, Gremm S, Harmann T. Profiling of alzheimer's disease related genes in mild to moderate vitamin D hypovitaminosis. The Journal of Nutritional Biochemisty. May 2019;67:123-137. Doi:10.1016/j.jnutbio.2019.01.015

16.Wang L, Ying J, Fan P, Weamer E, DeMichele-Sweet M, Lopez O, Kofler J, Sweet R. Effects of vitamin D use on outcomes of psychotic symptoms in alzheimers disease patients. September 2019;27(9):908-917. Doi:10.1016/j.jagp.2019.03.016

Dont think saturated fats, think trans fatty acids

1. Cui Y, Hao P, Liu b, Meng X. Effect of traditional chinese cooking methods on fatty acid profiles of vegetable oil. October 2017:233:77-84. Doi:10.1016/j.foodchem.2017.04.084

2. Orsavova J, Misurcova L, Ambrozova J, Vicha R, Mlcek J. Fatty acids composition of vegetable oils and its contribution to dietary energy intake and dependence of cardiovascular mortality on dietary intake of fatty acids. 2015; 16(6):12871-12890. Doi:10.3390/ljims.160612871

3. De Souza R, Mente A, Maroleanu A, Cozma A, Ha V, Kishibe T, Uleryke E, Budylowski P, Schunemann H, Beyene J, Anand S. Intake of saturated and trans unsaturated fatty acids and risk of all cause mortality, cardiovascular disease, and type 2 diabetes: systematic review and meta-analysis of observational studies. Doi:10.1136/bmj.h3978

4. Ascherio A, Willett W. Health effects of trans patty acids. October 2010; 66(4):1006-1010. Doi:10.1093/ajcn/66.4.10065

5. Stender S, Dyerberg J. High levels of industrially produced trans fat in popular fast foods. April 2006; 6354: 1650-1652. Doi:10.1056/NEJMc052959

6. Oteng A, Loreggar A, van Weeghel M, Zelcer N, Kersten S. Trans fatty acids and serum cholesterol. October 2019; 63(19): 190385. Doi:10.1002/mnfr.201900395

7. Albuquerque T. Santos J, Silva M, Oliveira M, Costa H. An update on processed foods: Relationship between salt, saturated and trans fatty acids content. November 2018; 367: 75-82. Doi:10.1016/j.foodchem2018.01.019

8. Mazidi M, Vantanfarast H. Serum trans-fatty acids level are positively associated with lower food security among American adults. March 2018. Doi:10.1038/s41387-017-0008-7

9. Mozafarian D. Natural trans fat, dairy fat, partially hydrogenated oils, and cardiometabolic health: the Ludwigshafen Risk and Cardiovascular Health Study. April 2016; 37(13): 1079-1081. Doi:10.1093/eurheartj/ehv595

10.Hammad S, Pu S, Jones P. Current evidence supporting the link between dietary fatty acids and cardiovascular disease. May 2016; 51(5): 507-517

11.Astrup A. WHO draft guidelines on dietary saturated and trans fatty acids: time for a new approach. July 2019; 366:14137. Doi:10.1136/bmj.141377

12.Food Standards, Australia and New Zealand. Foodstandards.gov au/consumer/nutrition/transfat

13.Hung W, Hwang L, Shahidi F, Pan M, Wang Y, Ho C. Endogenous formation of trans fatty acids: Health implication and potential dietary intervention. Journal of Functional Foods. August 2016; 25:14-24. Doi:10.1016/1. Cavinato M, Waltenberger B, Baraldo G, Grade C, Stuppner H, Jansen-Durr P. Plant extracts and natural compounds used against UVB-induced phoageing. Augest 2017;18(4):499-515 Doi:10.1007/s10522-01709715-7Ademosun

Dementia, "A smoothie to remember".

2. A, Oboh G, Olpona A, Oveleye S, Adewuni T, Nwanna E. comparative study of chemical composition, in vitro inhibition of cholinergic and monoaminergic enzymes, and antioxidant potentilas of essential oil from peels and seeds of sweet orange. February 2016;40(1):53-60. Doi:10/1111/jfbc.12187

3. Gosslau A, Ho C, Li S. The role of rutin and diosmin, two citrus polyhydroxyflavones in disease prevention and treatment. March 2019;5:43-56. Doi:10.31665/JFB.2019.5177

4. De la Rubia O, sanchez C, Sabater P, Cayo B, Castillo S, Rochina M, Yang H. How does coconut oil affect cognitive performance in alzheimer’s patients? March 2017;34(2): 352-356

5. Zang L. Coconut oil decreases expression of amyloid precursor protein (APP) and secretion of amyloid peptides through inhibition of ADP-ribosylation factor 1 (ARF1). February 2019;1704:78-84. Doi:10.1016/j.brainres.2018.10.001

6.Hooper C, De Souto Barreto P, Pahor M, Weiner M, Vellas B. The relationship of omega 3 polyunsaturated fatty acids in red blood cell membranes with cognitive function and brain structure: a review focused on Alzeimer’s Disease. The Journal of Prevention of Alzheimer’s Disease. Janurary 2018;5(1): 78-84.

7. Calder P. Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance. April 2015;1854(4):468-484. Doi:10.1016/j.bbalip.2014.08.010

8. Vlachos G, Scarmeas N. Dietary interventions in mild cognitive impairment and dementia. Dialogues in Clinical Neuroscience. 2019;21(1):69-82.

9. Price B, Wilcock D, Wiikman E. Hyperhomocysteinemia as a risk factor for vascular contributions to cognitive impairment and dementia. Frontiers in Ageing Neuroscience.Doi:10.2289/fnagi.2018.00350 10. 10. 10.Smith A, Refsum H. Homocysteine, B vitamins and cognitive impairment. July 2016;36:211-239. Doi:1146/annaurev-nutr-07175-050947

11.Jain R, Venkatasubramanian P. Sugarcane molasses – A potential dietary supplement in the management of iron deficiency anemia. January 2017; 14(5): 589-598

12.Pizzato G, Piovesan F, Trevisan C, Veronese N, Manzato E. Effects of acetyl-L-carnitine in diabetic neuropathy and other geriatric disorders. February 2018;30(2):133-138. Doi:10.1007/s40520-017-0770-3

13.Yang Y, Choi H, Lee C, Kim Y, Kwak Y. A multicenter, randomized, double-blind, placebo-controlled clinical trial for efficacy of acetyl-L-carnitine in patients with dementia associated with cerebrovascular disease. March 2018;17(1):133-138. Doi:10.12779/dnd.2018.17.1.1

14.Adalier N, Parker H. vitamin E, turmeric and saffron in treatment of Alzheimer's disease. October 2016;5(4):40. Doi:10.3390/antiox5040040

Eat your greens? Now we know why.

1. Cohen A, Burgos-Aceves M, Bar-Ziv N, Smith Y. Cruciferous vegetables consumption and lung cancer prevention: Epidemological studies and molecular mechanisms. December 2018. Doi:10.21037/jxym.2019.04.01

2. Abbaoui B, Lucas C, Riedl K, clinton S, Mortazavi A. Cruciferous vegetables, isothiocyanates, and bladder cancer prevention. September 2018; 62(18). Doi:10.1002/mnfr.201800079

3. Parsons J, Pierce J, Mohler J, Paskett E, Jung S, Morris M, Small E, Hahn O, Humphrey P, Taylor J, Marshall J. Men's eating and living (MEAL) study (CALG 70807) [Alliance] recruitment feasibility and baseline demographics of a randomized trial of diet in men on active surveillance for prostate cancer. April 2018; 121(4): 534-539. Doi:10.1111/bju13890

4. Amjad A, Parikh R, Appleman L, Hahm E, Singh K, Singh S. Broccoli-derived sulforaphane and chemoprevention of prostate cancer: from bench to bedside. December 2015; 1(6): 382-390. Doi:10.1007/s40495-015-0034-x

5. Su x, Jiang X, Meng L, Dong x, Shen Y, Xin Y. Anticancer activity of sulforaphane: The epigenetic mechanisms and the Nrf2 signalling pathways. Oxidative Medicine and Cellular Longevity. Doi:10.1155/2018/5438179

6. Kaczmared J, Liu X, Charron C, Novotny J, Jeffery E, Seifried H, Ross S, Miller M, Swanson K, Holscher H. Broccoli consumption affects the human gastrointestinal microbiota. January 2019; 63: 27-34. Doi:10.1016/j.jnutbio.2018.09.015

7. Armesto J, Gomez-Limia L, Carballo J, Martinez S. Effects of different cooking methods on the antioxidant capacity and flavonoid, organic acid and mineral contents of Galega Kale (Brassica oleracea var. Acephala cv. Galaga) July 2019; 70(2): 136-149. Doi:10.1080/09637486.2018.14.82530

The wonders of cinnamon

1. Mousave S, Rahmani J, Kord-Varkaneh H, Sheikhi A, Laarijiani B, Esmallzadeh A. Cinnamon

supplementation positively affects obesity: a systematic review and dose-responsive meta-analysis of randomized controlled trials. Clinical Nutrition. Doi: 10.1016/j.clnu.2019.02.017

2. Zare R, Nadjarzadeh A, Zarshenas M, Shams M, Heydari M. Effacacy of cinnamon in patients with type 11 diabetes mellitus: A randomized controlled trial. Clinical nutrition. April 2019; 38(2): 549-556. Doi: 10.1016/j.clnu.2018.03.003

3. Maierean S. Serban M, Sahebkar A, Ursonie S. McPharm P, Banach M. The effects of cinnamon supplementation on blood lipid concentrations: A systematic review and meta-analysis. Journal of Clinical Lipidology. November 2017;11(6): 1393-1406. Doi:10.1016/j.jad.2017.08.004

4. Salib A. Anti-diabetic and antioxidant effect of cinnamon in poorly controlled diabetic Iraqi patients: A randomized, placebo-controlled clinical trial. April 2016; 5(2): 108-113. Doi: 10.5455/jice.2016021704445511

5. Reddy H, Manczak M, Yin X, Grady M. Protective effects of Indian spice curcumin against amyloid Beta in Alzheimers disease February 2018; 61(3): 843-866. Doi: 10.3233/JAD-170512

6. Rao P, Gan S. Cinnamon: A multifaceted medicinal plant. Evidence-based Complementary and Alternative Medicine. Doi: 10.1155/2014/642942

Is turmeric just another fad?

1. Bone K, Mills S. Principles and practice of phytotherapy. 2nd ed. China: Churchill Livingston;2013. Pp900,918

2. Li S, Yuan W, Deng G, Wang P, Yang P, Aggarwal B. Chemical composition and product quality control of turmeric (curcuma longs L.) Pharmaceutical crops. 2011;2:28-54

3. Reddi P. A touch of turmeric: examining an Ayurvedic treasure. May2013;3(2):91-95. Doi:10.4236/aa.2013.32012

4. Goh K, Changing trends in gastrointestinal disease in the Asian-Pacific region. October 2007; 8(4):179-185. Doi:10.1111/j.1751.2980.2007.00304

5. Yue G, Jiang L, Kwak H, Lee J, Chan K, Fung K, Leung P, Sau C. Turmeric ethanolic extract possesses stronger inhibitory activities on colon tumor growth than curcumin-the importance of turmerones. April 2016;22:565-577. Doi:10.1016/j.jff.2016.02.011

6. Shen L, Liu C, An C, Ji H. How does curcumin work with poor bioavailability? Clues on experimental and theoretical studies. 2016;6:20872. Doi:10.1038/srep20872

7. Yue G, Cheng S, Yu H, Xu Z, Lee J, Hon P, Lee M, Kennelly E, Deng G, Yeung S, Cassileth B, Fung K, Leung P, Lau C. The role of turmerones on curcumin transportation and P-Glycoprotein activities in intestinal caco-2 cells. February 2012; 15(3)

8. Aggarwal B, Yuan W, Li S, Gupta S. Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: indentification of novel components of turmeric. September 2013; 57(9): 1529-1542. Doi:10.1002/mnfr.2012.00838

9. Prasad S, Tyagi A, Aggarwas B. Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment of golden spice. January 2014; 46(1):2-18. Doi:10.4143/crt.2014.1.2

10.Salehi B, Stojanovic-Radic Z, matejic J, Sharifi-Rad M, Kumar N, Marins N, Sharifi-Rad J. The therapeutic potential of curcumin: A review of clinical trials. February 2019; 163(1):527-545. Doi:10.1016/j.ejmech.2018.12.016

The benefits of ABC juice